| Identification | Back Directory | [Name]
N-Boc-PEG4-bromide | [CAS]
1392499-32-9 | [Synonyms]
Br-PEG4-NHBoc
N-Boc-PEG4-bromide
N-Boc-PEG5-bromide
BocNH-PEG4-CH2CH2Br
5,8,11,14-Tetraoxa-2-azahexadecanoic acid, 16-bromo-, 1,1-dimethylethyl ester | [Molecular Formula]
C15H30BrNO6 | [MDL Number]
MFCD31536756 | [MOL File]
1392499-32-9.mol | [Molecular Weight]
400.31 |
| Chemical Properties | Back Directory | [Boiling point ]
459.3±40.0 °C(Predicted) | [density ]
1.223±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DCM | [form ]
Liquid | [pka]
12.23±0.46(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Description]
N-Boc-PEG4-bromide is a PEG linker containing a bromide group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine. | [Biological Activity]
N-Boc-PEG5-bromide is a PROTAC linker that belongs to the PEG class and the Alkyl/ether class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). | [in vitro]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
| Cleavable | PEGs | Alkyl/ether | |
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