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ChemicalBook--->CAS DataBase List--->1386980-55-7

1386980-55-7

1386980-55-7 Structure

1386980-55-7 Structure
IdentificationBack Directory
[Name]

Pyrido[2,3-d]pyrimidine-6-carboxamide, N-[5-[[(3-amino-1-phenylpropyl)amino]carbonyl]-2-chlorophenyl]-7,8-dihydro-2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-7-oxo-, hydrochloride (1:1)
[CAS]

1386980-55-7
[Synonyms]

Pyrido[2,3-d]pyrimidine-6-carboxamide, N-[5-[[(3-amino-1-phenylpropyl)amino]carbonyl]-2-chlorophenyl]-7,8-dihydro-2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-7-oxo-, hydrochloride (1:1)
[Molecular Formula]

C30H31Cl2N7O4
[MOL File]

1386980-55-7.mol
[Molecular Weight]

624.52
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 20.83 mg/mL (33.35 mM; ultrasonic and warming and heat to 60°C)
[form ]

Solid
[color ]

Yellow to brown
Hazard InformationBack Directory
[Biological Activity]

DYRKs-IN-1 hydrochloride is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. DYRKs-IN-1 hydrochloride has antitumor activity[1][2]. DYRKs-IN-1 hydrochloride (compound 30) increases the cellular potency against the human colon tumor cell line SW 620 with an EC50 of 27 nM[1]. DYRKs-IN-1 hydrochloride (Example 183) is a potent DYRKs inhibitor[2].
[References]

[1]. Anderson K, et al. Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6610-5. [2]. Kevin Anderson, et al. Pyrido pyrimidines. US20120184542A1.
1386980-55-7 suppliers list
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Website: www.aladdinsci.com/
Company Name: Shanghai?Medlife?Pharm-Tech?Co.,?Ltd  
Tel: 021-59167510 18117107507
Website: www.med-life.cn/
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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