| Identification | Back Directory | [Name]
2-Propenamide, 2-cyano-3-(3,5-dichlorophenyl)-3-hydroxy-N-[4-(trifluoromethyl)phenyl]- | [CAS]
136186-07-7 | [Synonyms]
TPC2-A1-N
2-Propenamide, 2-cyano-3-(3,5-dichlorophenyl)-3-hydroxy-N-[4-(trifluoromethyl)phenyl]- | [Molecular Formula]
C17H9Cl2F3N2O2 | [MDL Number]
MFCD32878270 | [MOL File]
136186-07-7.mol | [Molecular Weight]
401.17 |
| Chemical Properties | Back Directory | [Boiling point ]
536.9±50.0 °C(Predicted) | [density ]
1.546±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [pka]
5.05±0.60(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
TPC2-A1-N is a selective two pore segment channel 2 (TCP2) agonist th at mimics the action of NAADP where it selectively induces fast Ca2+ signals (EC50 = 7.8 μM) in a TCP2-dependent mannerwithout potency toward TRPML1/2/3. In contrastTPC2-A1-N is a much weaker Na+ current inducer when compared to PI(3,5)P2 and TPC2-A1-P. TPC2-A1-Nbut not the Na+ signals agonist TPC2-A1-P causes TPC2-dependent alkalinization of lysosomal lumen Ca2+ stores (10 μMTPC2-expressing HeLa cells)while TPC2-A1-Pbut not TPC2-A1-Nactivates TPC2-dependent lysosomal exocytosis (30 μMmurine macrophages). |
|
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|