| Identification | Back Directory | [Name]
4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE | [CAS]
135721-98-1 | [Synonyms]
S14506HCl
S 14506 HYDROCHLORIDE
1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride
4-Fluoro-N-(2-(4-(7-Methoxynaphthalen-1-yl)piperazin-1-yl)ethyl)benzaMide hydrochloride
4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE | [Molecular Formula]
C24H27ClFN3O2 | [MDL Number]
MFCD00910294 | [MOL File]
135721-98-1.mol | [Molecular Weight]
443.94 |
| Hazard Information | Back Directory | [Uses]
S 14506 is a full, highly potent and selective SR-1A agonist. | [Definition]
ChEBI: 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide hydrochloride is a hydrochloride salt that is obtained by reaction of 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide with one equivalent of hydrogen chloride. Highly potent selective 5-HT1A receptor full agonist (pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo. It has a role as a serotonergic agonist and an anxiolytic drug. It contains a 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide(1+). | [Biological Activity]
Highly potent selective 5-HT 1A receptor full agonist (pK i values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT 1A , 5-HT 1B , 5-HT 1C , 5-HT 2 and 5-HT 3 receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo . |
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