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ChemicalBook--->CAS DataBase List--->1341224-83-6

1341224-83-6

1341224-83-6 Structure

1341224-83-6 Structure
IdentificationBack Directory
[Name]

INCB8761(PF-4136309)
[CAS]

1341224-83-6
[Synonyms]

CS-1440
EOS-61910
NCB8761(PF-4136309)
INCB8761(PF-4136309)
PF-04136309(INCB-8761)
ZNSVOHSYDRPBGI-LXWOLXCRSA-N
N-(2-((S)-3-(((1R,4S)-4-HYDROXY-4-(5-(PYRIMIDIN-2-YL)
INCB8761; PF-4136309; PF4136309; PF 4136309; INCB-8761
Benzamide, N-[2-[(3S)-3-[[trans-4-hydroxy-4-[5-(2-pyrimidinyl)-2-pyridinyl]cyclohexyl]amino]-1-pyrrolidinyl]-2-oxoethyl]-3-(trifluoromethyl)-
N-(2-((S)-3-(((1r,4S)-4-hydroxy-4-(5-(pyrimidin-2-yl) yridine-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide
[Molecular Formula]

C29H31F3N6O3
[MOL File]

1341224-83-6.mol
[Molecular Weight]

568.59
Chemical PropertiesBack Directory
[Boiling point ]

712.2±60.0 °C(Predicted)
[density ]

1.40±0.1 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
[solubility ]

Soluble in DMSO (up to at least 25 mg/ml)
[form ]

solid
[pka]

13.17±0.46(Predicted)
[color ]

Off-white
[Stability:]

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
[HS Code ]

2933998090
Hazard InformationBack Directory
[Description]

PF-4136309 is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50s = 5.2, 13, and 17 nM for the human, rat, and mouse receptors, respectively). It also inhibits the voltage-gated potassium channel subtype Kv11.1 by 35% when used at a concentration of 10 μM. PF-4136309 decreases isolated human monocyte chemotaxis induced by chemokine (C-C motif) ligand 2 (CCL2) with an IC50 value of 3.9 nM.
[Uses]

PF 4136309 is a CCR5 receptor antagonists that contributes to the treatment of rheumatoid arthritis.
[References]

1) Chu-Biao?et al.?(2011),?Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist;?ACS Med. Chem. Lett.?2?913 2) Sanford?et al.?(2013),?Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis;?Clin. Cancer Res.?19?3404 3) Nywenig?et al.?(2016),?Phase 1b study targeting tumor associated macrophages with CCR2 inhibition plus FOLFIRINOX in locally advanced and borderline resectable pancreatic cancer;?Lancet Oncol.?17?651
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