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ChemicalBook--->CAS DataBase List--->133876-92-3

133876-92-3

133876-92-3 Structure

133876-92-3 Structure
IdentificationBack Directory
[Name]

Nattokinase
[CAS]

133876-92-3
[Synonyms]

NattoLife
Natokonase
Nattokinase
Nattokinease
Nattoesse Haruno-Ogawa
NATTOKINASE 20,000 FIP
Nattokinase (peptidolytic)
Nattokinase extract:Nattoesse extract
Liposomal NATTOKINASE, NATTOKINASE NanoEmulsion, NanoActive NATTOKINASE, Oil-Soluble NATTOKINASE
4-(Carboxymethyl)-2-[(1R)-1-{[N-(2,5-dichlorobenzoyl)glycyl]amino}-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid
4-(carboxymethyl)-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-carboxylic
4-(carboxymethyl)-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid
[EINECS(EC#)]

229-880-6
[Molecular Formula]

N/A
[MOL File]

133876-92-3.mol
[Molecular Weight]

517.122
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to off-white
[InChIKey]

YTXSYWAKVMZICI-VVSYKVCONA-N
[SMILES]

O1C(=O)CC(CC(O)=O)(C(O)=O)OB1[C@@H](NC(CNC(=O)C1=CC(Cl)=CC=C1Cl)=O)CC(C)C |&1:14,r|
Hazard InformationBack Directory
[Chemical Properties]

Nattokinase is an enzyme (a protein that speeds up biochemical reactions) that is extracted from a popular Japanese food called natto. Natto is boiled soybeans that have been fermented with a bacterium called Bacillus natto. 
[Uses]

Although nattokinase is promoted for use as a fibrinolytic and thrombolytic agent, clinical trials are lacking to support such use. There is also no substantial evidence that nattokinase lowers blood pressure in hypertension.
[Mechanism of action]

Nattokinase decreases the ability of blood to clot. This "thins the blood" and might protect against conditions caused by blood clots such as stroke, heart attack, and others.
[Side effects]

Small, short-term trials evaluating nattokinase reported no adverse reactions. There is a theoretical risk of bleeding, based on a case report of acute cerebellar hemorrhage in a patient with a history of ischemic stroke. Thrombosis was reported after substitution of nattokinase for warfarin in a patient with a mechanical aortic valve. Rare cases of late-onset anaphylaxis with natto have been attributed to poly-gamma-glutamic acid, a product of the fermentation process that may be present in nattokinase supplements.
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