| Identification | Back Directory | [Name]
TYRPHOSTIN B56 | [CAS]
133550-41-1 | [Synonyms]
AG 556
TYRPHOSTIN B56
TYRPHOSTIN AG 556
AG 556 (Tyrphostin AG 556)
ALPHA-CYANO-(3,4-DIHYDROXY)-N-(4-PHENYLBUTYL)CINNAMIDE
N-(4-PHENYLBUTYL)-3,4-DIHYDROXYBENZYLIDENE-CYANOACETAMIDE
2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)acrylamide
(E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-(4-PHENYLBUTYL)-2-PROPENAMIDE
(2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-2-propenamide
2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-, (2E)-
N-(4-Phenylbutyl)-3,4-dihydroxybenzylidenecyanoacetamide, Tyrphostin B56 | [Molecular Formula]
C20H20N2O3 | [MDL Number]
MFCD00209860 | [MOL File]
133550-41-1.mol | [Molecular Weight]
336.38 |
| Hazard Information | Back Directory | [Uses]
AG 556 is a highly selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TK inhibitor). AG 556 has been shown to decrease human atrial IKur and cloned hKv1.5 channels by inhibiting EGFR TK. | [Biological Activity]
Epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 1.1 μ M). Selective over ErbB2 (IC 50 > 500 μ M). | [References]
[1]. zhang dy, zhang yh, sun hy, et al. epidermal growth factor receptor tyrosine kinase regulates the human inward rectifier potassium k(ir)2.3 channel, stably expressed in hek 293 cells. br j pharmacol, 2011 nov, 164(5): 1469-1478
[1].
[2]. zhang dy, wu w, deng xl, et al. genistein and tyrphostin ag556 inhibit inwardly-rectifying kir2.1 channels expressed in hek 293 cells via protein tyrosine kinase inhibition. biochim biophys acta, 2011, 1808(8): 1993-1999.
[3]. kleinberger-doron n, shelah n, capone r, et al. inhibition of cdk2 activation by selected tyrphostins causes cell cycle arrest at late g1 and s phase. exp cell res, 1998, 241(2): 340-351.
[4]. sevransky je, shaked g, novogrodsky a, et al. tyrphostin ag 556 improves survival and reduces multiorgan failure in canine escherichia coli peritonitis. j clin invest, 1997, 99(8): 1966-1973. |
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