| Identification | Back Directory | [Name]
Entecavir Impurity | [CAS]
1333204-94-6 | [Synonyms]
Entecavir Impurity
Entecavir Hydrate IMP
(1R,3S,4S)-ent-Entecavir
6H-Purin-6-one, 2-amino-1,9-dihydro-9-[(1R,3S,4R)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-, rel- | [Molecular Formula]
C12H15N5O3 | [MDL Number]
MFCD11100789 | [MOL File]
1333204-94-6.mol | [Molecular Weight]
277.28 |
| Hazard Information | Back Directory | [Uses]
(1R,3S,4S)-Entecavir is an impurity of Entecavir (E558900). | [Definition]
ChEBI: Entecavir (anhydrous) is guanine substituted at the 9 position by a 4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl group. A synthetic analogue of 2'-deoxyguanosine, it is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus. Entecavir is phosphorylated intracellularly to the active triphosphate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. It is used for the treatment of chronic hepatitis B. It has a role as an EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor and an antiviral drug. It is a member of 2-aminopurines, an oxopurine, a primary alcohol and a secondary alcohol. |
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