| Identification | Back Directory | [Name]
Piperidine, 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]- | [CAS]
1318793-78-0 | [Synonyms]
YSK05
Piperidine, 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]- | [Molecular Formula]
C42H77NO2 | [MOL File]
1318793-78-0.mol | [Molecular Weight]
628.07 |
| Chemical Properties | Back Directory | [Boiling point ]
663.6±55.0 °C(Predicted) | [density ]
0.91±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Ethanol: 25 mg/ml | [form ]
Liquid | [pka]
7.51±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
YSK05 is an ionizable amino lipid (apparent pKa = ~6.5) that has been used in combination with other lipids in the formation of liposomes and lipid nanoparticles (LNPs).1,2,3 Administration of cyclic di-GMP in YSK05-containing liposomes increases serum levels of IFN-β, IFN-γ, IL-6, and TNF-α and activates natural killer (NK) cells in mice, as well as decreases lung metastasis in a B16/F10 murine melanoma model of metastasis.2 Intravenous administration of factor VII siRNA in YSK05-containing LNPs reduces factor VII activity in isolated mouse plasma.3 | [References]
1.Sato, Y., Hatakeyama, H., Sakurai, Y., et al.A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivoJ. Control. Release163(3)267-276(2012)
2.Nakamura, T., Miyabe, H., Hyodo, M., et al.Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanomaJ. Control. Release216149-157(2015)
3.Sato, Y., Note, Y., Maeki, M., et al.Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA deliveryJ. Control. Release22948-57(2016)
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| Company Name: |
DC Chemicals
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021-58447131 13564518121 |
| Website: |
http://www.is0513.com/ShowSupplierProductsList927327/0.htm |
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