| Identification | Back Directory | [Name]
PF-5006739 | [CAS]
1293395-67-1 | [Synonyms]
PF-5006739
PF 5006739;PF5006739
PF-5006739 >=98% (HPLC)
4-[5-(4-fluorophenyl)-3-[1-(1,2-oxazol-3-ylmethyl)piperidin-4-yl]imidazol-4-yl]pyrimidin-2-amine
4-[4-(4-Fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-2-pyrimidinamine
2-Pyrimidinamine, 4-[4-(4-fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]- | [Molecular Formula]
C22H22FN7O | [MDL Number]
MFCD28386023 | [MOL File]
1293395-67-1.mol | [Molecular Weight]
419.45 |
| Hazard Information | Back Directory | [Biochem/physiol Actions]
PF-5006739 is a potent inhibitor of casein kinases 1 delta (CK1δ) and 1 epsilon (CK1ε), key regulators of the suprachiasmatic nucleus (SCN) central clock and also linked to the development of drug addiction through PERIOD proteins (PER1–3) and dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) modulation. PF-5006739 has low nM in vitro potency for CK1δ/ε (IC50 values of 3.9 nM for CK1δ and 17.0 nM for CK1ε) and high kinome selectivity. PF-5006739 induced profound phase delays in circadian periodicity in both nocturnal and diurnal animal models and attenuated opioid drug-seeking behavior in a rodent operant reinstatement model. | [storage]
Store at +4°C |
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BOC Sciences
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Sigma-Aldrich
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DC Chemicals
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