| Identification | Back Directory | [Name]
BocNH-PEG7-OH | [CAS]
1292268-13-3 | [Synonyms]
BocNH-PEG7-OH
NHBoc-PEG7-OH
t-boc-N-amido-PEG7-alcohol
t-butyl20-hydroxy-3,6,9,12,15,18-hexaoxaicosylcarbamate
5,8,11,14,17,20-Hexaoxa-2-azadocosanoic acid, 22-hydroxy-, 1,1-dimethylethyl ester | [Molecular Formula]
C19H39NO9 | [MDL Number]
MFCD29049415 | [MOL File]
1292268-13-3.mol | [Molecular Weight]
425.51 |
| Chemical Properties | Back Directory | [Boiling point ]
521.1±50.0 °C(Predicted) | [density ]
1.090±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [pka]
12.23±0.46(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
N-Boc-PEG7-alcohol is a PEG linker containing a hydroxyl group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine. | [Biological Activity]
N-Boc-PEG7-alcohol is a PROTAC bridge that belongs to the PEG class and the Alkyl/ether class. It can be used to synthesize a series of PROTAC molecules. Also it is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). | [in vitro]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
| Cleavable | PEGs | Alkyl/ether | |
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