| Identification | Back Directory | [Name]
MI-3 (Menin-MLL Inhibitor) | [CAS]
1271738-59-0 | [Synonyms]
MI-3
CS-1809
5-dihydro-5
Menin-MLL inhibitor 3
MI-3 (Menin-MLL Inhibitor)
MI-3 (Menin-MLL Inhibitor) USP/EP/BP
5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)
4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine
Thieno[2,3-d]pyriMidine, 4-[4-(4,5-dihydro-5,5-diMethyl-2-thiazolyl)-1-piperazinyl]-6-(1-Methylethyl)-
4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine MI-3
MI3;MI 3;MENIN-MLL INHIBITOR 3;THIENO[2;3-D]PYRIMIDINE; 4-[4-(4;5-DIHYDRO-5;5-DIMETHYL-2-THIAZOLYL)-1-PIPERAZINYL]-6-(1-METHYLETHYL) | [Molecular Formula]
C18H25N5S2 | [MDL Number]
MFCD28348362 | [MOL File]
1271738-59-0.mol | [Molecular Weight]
375.555 |
| Chemical Properties | Back Directory | [Boiling point ]
527.9±60.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 8.33 mg/mL (22.18 mM; Need ultrasonic) | [form ]
Powder | [pka]
9.59±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
MI-3 is an inhibitor of the interaction between menin and mixed lineage leukemia (MLL) fusion proteins (IC50 = 648 nM).1 MI-3 binds to menin (Kd = 201 nM) and inhibits the menin interaction with the MLL fusion protein MLL-AF9 in HEK293 cells without affecting protein levels of menin or MLL-AF9. It inhibits growth of mouse bone marrow cells (BMCs) expressing the Hoxa9 transformation-dependent MLL fusion proteins MLL-AF9 or MLL-ENL (IC50 = 5 μM for both), as well as reduces colony formation and induces differentiation of MLL-AF9-transformed BMCs. MI-3 inhibits growth of human leukemia cell lines containing MLL translocations and decreases the expression of the transcription factors HOXA9, HOXA10, and MEIS1 in THP-1 cells. | [Uses]
MI-3 (Menin-MLL Inhibitor) reverses oncogenic activity of MLL fusion proteins in leukemia. |
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| Company Name: |
D&C Chemicals
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+86-21-58447131 |
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www.is0513.com/ShowSupplierProductsList16963/0.htm |
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