| Identification | Back Directory | [Name]
S1RA (hydrochloride) | [CAS]
1265917-14-3 | [Synonyms]
177303
S1RA. HCL
S1RA (E-52862) HCI
S1RA HCl (E-52862)
E52862 hydrochloride
S1RA (hydrochloride)
E 52862 hydrochloride
E-52862 hydrochloride
E-52862 HYDROCHLORIDE;E52862 HYDROCHLORIDE;E 52862 HYDROCHLORIDE
4-(2-(5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy)ethyl)morpholine hydrochloride
4-[2-[[5-Methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride (1:1) | [EINECS(EC#)]
931-042-6 | [Molecular Formula]
C20H24ClN3O2 | [MDL Number]
MFCD27963345 | [MOL File]
1265917-14-3.mol | [Molecular Weight]
373.88 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C (des.) | [solubility ]
Soluble in DMSO (up to at least 25 mg/ml) | [form ]
solid | [color ]
Off-white | [Stability:]
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
S1RA (E-52862, 1265917-14-3) is a potent and selective σ1 antagonist with weak binding at σ2?(IC50?σ1 = 17nM, σ2 = 9300nM).1,2?S1RA abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute inflammation by enhancing the action of endogenous opioid peptides of immune origin in a σ1 dependent manner.3?S1RA potentiated μ-opioid antinociception in mice in a σ-dependent manner.4?S1RA displayed neuroprotective effects in a mouse model of ischemic stroke.5 | [References]
References/Citations |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
|
| Website: |
www.spiropharma.com.cn |
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