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ChemicalBook--->CAS DataBase List--->1254277-89-8

1254277-89-8

1254277-89-8 Structure

1254277-89-8 Structure
IdentificationBack Directory
[Name]

Termitomycamide B
[CAS]

1254277-89-8
[Synonyms]

Termitomycamide B
(9Z,12Z)-N-[2-(1H-indol-2-yl)-2-oxoethyl]octadeca-9,12-dienamide
[Molecular Formula]

C28H40N2O2
[MOL File]

1254277-89-8.mol
[Molecular Weight]

436.63
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 20 mg/ml; DMSO: 20 mg/ml
[form ]

A crystalline solid
Hazard InformationBack Directory
[Description]

Endoplasmic reticulum (ER) stress, caused by accumulation of misfolded proteins and a disruption of calcium homeostasis, has been linked to several neuronal diseases including, Parkinson’s, Alzheimer’s, and prion diseases. A screen for protective activity against ER stress-dependent cell death identified termitomycamides, extracts from the fruiting bodies of T. titanicus, a notably large edible mushroom that is cultivated symbiotically in the nests of termites Termitomycamide B is a fatty acid isolated from T. titanicus that at a dose of 0.1 μg/ml protects against ER stress-dependent cell death in Neuro2a cells induced by tunicamycin.
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