| Identification | Back Directory | [Name]
5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile hydrochloride | [CAS]
1234015-54-3 | [Synonyms]
LY2606368 2HCL
Prexasertib HCl
LY 2606368;LY-2606368
LY-2606368 (Prexasertib)
LY2606368 dihydrochloride
LY-2606368 dihydrochloride
Prexasertib HCl (LY2606368)
Prexasertib dihydrochloride
Prexasertib (LY2606368) 2HCl
LY 2606368;LY-2606368;PREXASERTIB DIHYDROCHLORIDE
5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile hydrochloride
5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile dihydrochloride | [Molecular Formula]
C18H21Cl2N7O2 | [MOL File]
1234015-54-3.mol | [Molecular Weight]
438.311 |
| Chemical Properties | Back Directory | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMSO:12.5(Max Conc. mg/mL);28.52(Max Conc. mM) | [form ]
Solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
Prexasertib HCl is a member of the serine/threonine protein kinase family and is the core protein of cell cycle checkpoints in DNA damage response (DDR). | [Biological Activity]
Prexasertib HCl is an ATP-competitive inhibitor of CHK1 with a Ki value of 0.9 nM. In cell-free experiments, the IC50 values of it for CHK2 and RSK were 8 nM and 9 nM, respectively. | [target]
| Target | Value | Chk1
(Cell-free assay) | 0.9 nM(Ki) | Chk2
(Cell-free assay) | 8 nM | < tr> RSK
(Cell-free assay) | 9 nM |
| [storage]
Store at -20°C |
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