| Identification | Back Directory | [Name]
(S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine | [CAS]
1227163-84-9 | [Synonyms]
CS-2630
(S)-AZD3839
AZD3839 fuMarate
AZD3839 (free base)
AZD3839;AZD-3839;AZD 3839
(S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine
1H-Isoindol-3-amine, 1-[2-(difluoromethyl)-4-pyridinyl]-4-fluoro-1-[3-(5-pyrimidinyl)phenyl]-, (1S)-
(S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine AZD3839 | [EINECS(EC#)]
682-619-1 | [Molecular Formula]
C24H16F3N5 | [MDL Number]
MFCD25976574 | [MOL File]
1227163-84-9.mol | [Molecular Weight]
431.41 |
| Chemical Properties | Back Directory | [Boiling point ]
596.3±60.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (289.75 mM; Need ultrasonic) | [form ]
Powder | [pka]
2.56±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
AZD3839 is a potent and selective BACE1 inhibitor (Ki = 26.1 nM/BACE1372.4 nM/BACE2>25 μM/Cathepsin D by cell-free TR-FRET; hERG IC50 = 4.8 μM) th at effectively suppresses cellular BACE1 activity in neuron cultures (sAPPβ release IC50 = 16.7 nM/SH-SY5Y; Aβ40 release IC50 = 4.8 nM/SH-SY5Y AAP695wt32.2 nM/N2A24.8 nM/guinea pig cortical neurons51 nM/murine cortical neurons) and exhibits in vivo Aβ40-Aβ42-sAPPβ-reducing efficacy (80 & 160 μmol/kg mousep.o.; 100 & 200 μmol/kg guinea pigsp.o.2.5 & 20 μmol/kg cynomolgus monkeysi.v.) with good pharmacokinetic properties and oral availability. |
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BOC Sciences
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Musechem
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DC Chemicals
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