| Hazard Information | Back Directory | [Description]
Brinzolamide-d5 is intended for use as an internal standard for the quantification of brinzolamide by GC- or LC-MS. Brinzolamide is a potent inhibitor of carbonic anhydrase II (CAII) and CAIV (IC50s = 3.19 and 45.3 nM, respectively). It is selective for CAII and CAIV over CAI (IC50 = ~1,365 nM). Brinzolamide (30 mg/kg) reduces intestinal charcoal meal progression by 44% and prolongs pentobarbital sodium-induced sleep time by 35% in mice. Topical administration of brinzolamide (0.25, 0.5, and 1 mg/eye) reduces intraocular pressure in a rabbit model of spontaneous ocular hypertension. It also reduces intraocular pressure in a cynomolgus monkey model of argon laser trabeculoplasty-induced ocular hypertension. Formulations containing brinzolamide have been used in the treatment of glaucoma and ocular hypertension. | [Chemical Properties]
Crystalline Solid | [Uses]
Carbonic anhydrase inhibitor. Antiglaucoma agent. | [storage]
Store at -20°C |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
|
| Tel: |
58896805 |
| Website: |
http://www.is0513.com/ShowSupplierProductsList1748115/0.htm |
| Company Name: |
Pharma Affiliates
|
| Tel: |
172-5066494 |
| Website: |
http://www.is0513.com/ShowSupplierProductsList694812/0.htm |
|