| Identification | Back Directory | [Name]
7H-Pyrrolo[3,2-f]quinazoline-1,3-diaMine, N3-cyclopropyl-7-[[4-(1-Methylethyl)phenyl]Methyl]-, (Hydrochloride) (1:2) | [CAS]
1216720-69-2 | [Synonyms]
SCH 79797 (hydrochloride)
7H-Pyrrolo[3,2-f]quinazoline-1,3-diaMine, N3-cyclopropyl-7-[[4-(1-Methylethyl)phenyl]Methyl]-, (Hydrochloride) (1:2) | [Molecular Formula]
C23H25N5 | [MDL Number]
MFCD04039788 | [MOL File]
1216720-69-2.mol | [Molecular Weight]
371.478 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at 2-8°C, protect from light | [solubility ]
Soluble to 25 mM in ethanol and to 50 mM in DMSO | [form ]
Powder | [color ]
White to yellow |
| Hazard Information | Back Directory | [Description]
SCH 79797 is a non-peptide antagonist of proteinase-activated receptor 1 (PAR1). It blocks binding of the high affinity thrombin receptor-activating peptide (haTRAP) (IC50 = 70 nM) as well as platelet aggregation induced by either haTRAP or α-thrombin (IC50 = 0.3 and 3 μM, respectively). SCH 79797 has no activity against PAR2, PAR4, or other receptors involved in platelet activation. It also blocks PAR1 activation on vascular smooth muscle cells and endothelial cells. | [Uses]
N3-Cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine Dihydrochloride is a selective PAR1 antagonist which was shown to limit myocardial ischemia/reperfusion injury in rat hearts. | [storage]
Desiccate at RT |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
http://www.is0513.com/ShowSupplierProductsList927327/0.htm |
|