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ChemicalBook--->CAS DataBase List--->1215868-94-2

1215868-94-2

1215868-94-2 Structure

1215868-94-2 Structure
IdentificationBack Directory
[Name]

AMG-8718
[CAS]

1215868-94-2
[Synonyms]

AMG-8718
AMG 8718 (AMG-8718
(4S)-7'-(2-fluoropyridin-3-yl)-3'-[2-(3-methyloxetan-3-yl)ethynyl]spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-2-amine
[Molecular Formula]

C25H19FN4O3
[MDL Number]

MFCD28902223
[MOL File]

1215868-94-2.mol
[Molecular Weight]

442.44
Hazard InformationBack Directory
[Description]

AMG-8718 is a potent and orally efficacious BACE1 inhibitor. AMG-8718 produced robust and sustained reductions of CSF and brain Aβ levels in a rat pharmacodynamic model and exhibited significantly reduced potential for QTc elongation in a cardiovascular safety model. BACE1 (β-secretase, memapsin 2, Asp2) has emerged as a promising target for the treatment of Alzheimer's disease. BACE1 is an aspartic protease which functions in the first step of the pathway leading to the production and deposition of amyloid-β peptide (Aβ). BACE1 inhibition has direct implications in the Alzheimer's disease pathology without largely affecting viability.
1215868-94-2 suppliers list
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Company Name: AdooQ BioScience, LLC   
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Company Name: Absin Bioscience Inc.  
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Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
Company Name: BOC Sciences  
Tel: 16314854226
Website: www.bocsci.com
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