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ChemicalBook--->CAS DataBase List--->1215085-92-9

1215085-92-9

1215085-92-9 Structure

1215085-92-9 Structure
IdentificationBack Directory
[Name]

GLPG 0492
[CAS]

1215085-92-9
[Synonyms]

GLPG 0492
GLPG-0492 (GLPG0492)
4-[(4S)-4-(Hydroxymethyl)-3-methyl-2,5-dioxo-4-phenyl-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile
Benzonitrile, 4-[(4S)-4-(hydroxymethyl)-3-methyl-2,5-dioxo-4-phenyl-1-imidazolidinyl]-2-(trifluoromethyl)-
[Molecular Formula]

C19H14F3N3O3
[MOL File]

1215085-92-9.mol
[Molecular Weight]

389.33
Chemical PropertiesBack Directory
[Melting point ]

66 - 71°C
[Boiling point ]

544.0±60.0 °C(Predicted)
[density ]

1.50±0.1 g/cm3(Predicted)
[storage temp. ]

Hygroscopic, -20°C Freezer, Under inert atmosphere
[solubility ]

DMSO (Slightly), Ethanol (Slightly, Sonicated)
[form ]

Solid
[pka]

13.50±0.10(Predicted)
[color ]

White to Off-White
[Stability:]

Hygroscopic
Hazard InformationBack Directory
[Description]

GLPG0492 is a selective androgen receptor modulator (SARM). It activates the androgen receptor in a transactivation assay (EC50 = 12 nM in HeLa cells expressing the human receptor). GLPG0492 (10 mg/kg per day) increases levator ani muscle weight, a marker of anabolic activity, but has no effect on ventral prostate weight, a marker of androgenic activity, in castrated rats. It increases twitch tension in isolated diaphragm strips, as well as increases the total distance run in a treadmill test and decreases gastrocnemius muscle fibrosis in the exercised-mdx mouse model of muscular dystrophy when administered at a dose of 30 mg/kg. GLPG0492 also reverses immobilization-induced muscle atrophy in a mouse model of hindlimb immobilization.
[Uses]

GLPG-0492 is a non-steroidal Selective Androgen Receptor Modulator (SARM), which can be used to reduce muscle loss while sparing reproductive tissues.
Spectrum DetailBack Directory
[Spectrum Detail]

GLPG 0492(1215085-92-9)1HNMR
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