| Identification | Back Directory | [Name]
UNOPROSTONE | [CAS]
120373-36-6 | [Synonyms]
UNOPROSTONE
Unii-6X4F561V3w
Unoprostone [inn]
13,14-DIHYDRO-15-KETO-20-ETHYL PROSTAGLANDIN F2ALPHA
9ALPHA, 11ALPHA-DIHYDROXY-15-OXO-20A,20B-DIHOMOPROST-5-EN-1-OIC ACID
(E)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoic acid
5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl]-, (5Z)- | [Molecular Formula]
C22H38O5 | [MDL Number]
MFCD00865635 | [MOL File]
120373-36-6.mol | [Molecular Weight]
382.53 |
| Chemical Properties | Back Directory | [Boiling point ]
562.9±40.0 °C(Predicted) | [density ]
1.069±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 25 mg/ml; DMSO: 17 mg/ml; Ethanol: 12 mg/ml; PBS (7.2): 90 μg/ml | [pka]
4.76±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Unoprostane is a protectant against retinal degeneration in S334ter rhodopsin mutant rats. Neuroprotective agent. | [Definition]
ChEBI: Unoprostone is an oxo monocarboxylic acid, a prostaglandins Falpha and a ketone. It has a role as an antiglaucoma drug and an antihypertensive agent. | [General Description]
Unoprostone (Rescula) is supplied as a 0.15% sterileophthalmic solution. Unoprostone is somewhat unusual inthat it is a docosanoid (22-carbon atom) PGF2α analog marketedas the isopropyl ester. The natural 15-position alcoholis oxidized to the ketone as would be expected to occur invivo. Cautions and side effects are similar to those givenpreviously. |
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| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
|