| Identification | Back Directory | [Name]
1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione | [CAS]
1197377-31-3 | [Synonyms]
2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione
1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione
1-(2-chloro-1-hydroxy-3-(quinolin-6-yl)propyl)pyrrolidine-2,5-dione
2,5-Pyrrolidinedione, 1-[2-chloro-1-hydroxy-3-(6-quinolinyl)propyl]- | [EINECS(EC#)]
811-462-5 | [Molecular Formula]
C16H15ClN2O3 | [MDL Number]
MFCD30489249 | [MOL File]
1197377-31-3.mol | [Molecular Weight]
318.75 |
| Chemical Properties | Back Directory | [Boiling point ]
598.3±50.0 °C(Predicted) | [density ]
1.434±0.06 g/cm3(Predicted) | [vapor pressure ]
0-0Pa at 20-25℃ | [pka]
11.45±0.20(Predicted) | [InChI]
InChI=1S/C16H15ClN2O3/c17-12(16(22)19-14(20)5-6-15(19)21)9-10-3-4-13-11(8-10)2-1-7-18-13/h1-4,7-8,12,16,22H,5-6,9H2 | [InChIKey]
FUPWOFWDARMISK-UHFFFAOYSA-N | [SMILES]
N1(C(O)C(Cl)CC2=CC=C3C(=C2)C=CC=N3)C(=O)CCC1=O | [LogP]
0.9 at 20℃ and pH7 |
| Hazard Information | Back Directory | [Synthesis]
A solution of 3-quinolin-6-ylpropanal in acetonitrile was cooled to 0° C before L-proline, benzoic acid, and N-chlorosuccinimide were added at 0° C. The reaction mixture was stirred at 0° C for 3 h, and the resulting clear solution was allowed to warm to room temperature and stirred at RT for 18 h. The reaction mixture became a thick suspension, and LCMS showed the completion of the reaction. Ethyl acetate (EtOAc) was added to the reaction mixture, stirring at room temperature for 1 h. The solids were collected by filtration, washed with ethyl acetate, and dried under vacuum at 40-45° C to constant weight to afford 1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione as an off-white powder. yield: 65.![1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione](/NewsImg/2023-11-13/6383548140088645036596909.jpg "1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione") |
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