| Identification | Back Directory | [Name]
C.I. 37230 | [CAS]
119-93-7 | [Synonyms]
DMB
Tolidine
o-Tolidin
2-Tolidin
2-Tolidina
2-Tolidine
O-TOLIDINE
C.I. 37230
bianisidine
diaminotolyl
O-TolidineGr
3,3'-TOLIDINE
o,o’-tolidine
o,o'-Tolidine
ORTHO TOLIDINE
3 3,3-Tolidine
O-TOLIDINE, TECH.
DIMETHYLBENZIDINE
o-Tolidine, Powdero-tolidine solution
4,4'-BI-O-TOLUIDINE
rcrawastenumberu095
4,4'-Di-o-toluidine
4,4’-di-o-toluidine
[-C6H3(CH3)-4-NH2]2
3,3'-Dimethylbenzidin
3,3’-dimethylbenzidin
Fast Dark Blue Base R
3,3′-Dimethylbenzidine (o-Tolidine)
| [EINECS(EC#)]
204-358-0 | [Molecular Formula]
C14H16N2 | [MDL Number]
MFCD00014773 | [MOL File]
119-93-7.mol | [Molecular Weight]
212.29 |
| Chemical Properties | Back Directory | [Appearance]
o-Tolidine is a white to reddish crystal or powder. Darkens on exposure to air. Often used in paste or wet cake form. Used as a basis for many dyes. | [Melting point ]
128-131 °C(lit.)
| [Boiling point ]
300.5 °C
| [density ]
0.9678 (rough estimate) | [refractive index ]
n20/D 1.341
| [Fp ]
244 °C
| [storage temp. ]
?20°C | [solubility ]
2% HCl: 10 mg/mL, clear
| [Colour Index ]
37230 | [form ]
powder (may contain lumps)
| [pka]
4.59±0.10(Predicted) | [color ]
light brown
| [Water Solubility ]
Slightly soluble in water. | [Merck ]
14,9514 | [BRN ]
2210640 | [Exposure limits]
TLV-TWA none; carcinogenicity: A2 — Suspected Human Carcinogen (ACGIH), Animal
Limited Evidence (IARC). | [InChIKey]
NUIURNJTPRWVAP-UHFFFAOYSA-N | [IARC]
2B (Vol. 1, Sup 7) 1987 | [NIST Chemistry Reference]
| [EPA Substance Registry System]
[1,1'-Biphenyl]- 4,4'-diamine, 3,3'-dimethyl-(119-93-7) |
| Hazard Information | Back Directory | [Chemical Properties]
o-Tolidine(119-93-7) is a white to reddish crystal or powder and has an aniline-like odor. It is soluble in alcohol, ether, and dilute acid, but only slightly soluble in water. It has a tendency to darken when exposed to air and is commonly utilized in paste or wet cake form. This compound serves as a fundamental component for the production of numerous dyes. | [Uses]
o-Tolidine is used extensively in the manufacture of dyes, especially in the production of soluble azo dyes and insoluble pigments for the textile, leather, and paper sectors. Additionally, It is also used as a sensitive colorimetric reagent for the analysis of gold and free chlorine in water. | [General Description]
White to reddish crystals or crystalline powder or a light tan powder. | [Air & Water Reactions]
Insoluble in water. | [Reactivity Profile]
C.I. 37230 is sensitive to exposure to light. May be sensitive to prolonged exposure to air. A weak base that forms salts with hydrochloric acid or sulfuric acid. C.I. 37230 can be acetylated. Incompatible with strong agents . | [Fire Hazard]
Flash point data for C.I. 37230 are not available; however, C.I. 37230 is probably combustible. | [Potential Exposure]
Over 75% of o-tolidine is used as a dye and as an intermediate in the production of rubber products, dyestuffs, pigments and pesticides. Approximately 20% of o-tolidine is used in the production of polyurethane-based high-strength elastomers, coatings, and rigid plastics. o-Tolidine has also been used in small quantities in chlorine test kits by water companies and swimming pool owners. Used as a laboratory agent to detect blood. | [First aid]
Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Medical observation is recommended for 24-48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy. | [Shipping]
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required. | [Incompatibilities]
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, strong reducing agents. | [Description]
o-Tolidine, also called orthotolidine or 2-tolidine, is a chemical compound with the molecular formula (C6H4(CH3)NH2)2. It is a white to reddish-colored, combustible, aromatic amine that emits toxic fumes of nitrogen oxides when heated to decomposition. Several isomers are known; the 3-tolidine derivative is also important commercially. It is a colorless compound although commercial samples are often colored. It is slightly soluble in water. It forms salts with acids, such as hydrochloride, which is commercially available. 2-Tolidine can be produced by a benzidine rearrangement from a hydrazine derivative derived from 2-nitrotoluene. | [Waste Disposal]
Dissolve in flammable solvent and spray into firebox of an incinera tor equipped with afterburner and scrubber. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. | [Definition]
ChEBI: 3,3'-Dimethylbenzidine is a member of biphenyls. | [Preparation]
There are two commonly used methods for producing o-Tolidine(119-93-7). The first method involves reducing ortho-nitrotoluene to 1,2-diorthotolylhydrazine, which is then rearranged with acid. The second method involves reducing o-nitrotoluene using zinc dust and caustic soda, then converting the resulting hydrazotoluene to o-Tolidine by boiling it with hydrochloric acid. Once either of these methods is completed, o-Tolidine can be extracted and purified through techniques such as solvent extraction and recrystallization. | [Hazard]
Eye, bladder and kidney irritant, bladder
cancer, and methemoglobinemia. Possible carcinogen. | [Health Hazard]
The information on toxicity and carcinogenicity of o-tolidine is very little. o-Tolidineoften contains other biphenylamine contaminants. Its structure and chemical propertiesare similar to those of benzidine. The toxicproperties are therefore expected to be similar to those of benzidine.
o-Tolidine is absorbed into body throughthe skin, respiratory, and gastrointestinaltract. The acute oral and dermal toxicity wasmoderate in experimental animals. An oralLD50 value in rats is within the range of400 mg/kg.
o-Tolidine produced bladder cancer in testspecies. Also, cancers in other tissues werenoted in some animals. ACGIH lists thissubstance as a suspected human carcinogen. | [Carcinogenicity]
3,3′-Dimethylbenzidine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals. | [Purification Methods]
Dissolve the tolidine in *benzene by percolation through a column of activated alumina and crystallise it from *benzene/pet ether. [Beilstein 13 IV 410.] |
| Safety Data | Back Directory | [Hazard Codes ]
T,N,F | [Risk Statements ]
45-68-51/53-22-11 | [Safety Statements ]
53-45-61-16 | [RIDADR ]
UN 3082 9/PG 3
| [WGK Germany ]
3
| [RTECS ]
DD1225000
| [F ]
8 | [TSCA ]
Yes | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29215900 | [Safety Profile]
Confirmed carcinogen
with experimental carcinogenic and
tumorigenic data. Poison by intraperitoneal
route. Moderately toxic by ingestion.
Human mutation data reported. When
heated to decomposition it emits toxic
fumes of NOx. | [Hazardous Substances Data]
119-93-7(Hazardous Substances Data) | [Toxicity]
dog,LDLo,oral,600mg/kg (600mg/kg),Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 58, Pg. 167, 1907. |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
2-Nitrotoluene-->6-Amino-4-hydroxy-2-naphthalenesulfonic acid-->O-Tolidine | [Preparation Products]
disodium 3-[[4'-[(6-amino-1-hydroxy-3-sulphonato-2-naphthyl)azo]-3,3'-dimethoxy[1,1'-biphenyl]-4-yl]azo]-4-hydroxynaphthalene-1-sulphonate-->N,N'-(3,3'-Dimethyl-4,4'-biphenyldiyl)bis(3-oxobutanamide)-->DIRECT BLUE 15-->Sieber Linker-->ACID RED 114-->5-Amino-4-hydroxy-3-[[4'-[(1-hydroxy-4-sulfonaphthalen-2-yl)azo]-3,3'-dimethyl[1,1'-biphenyl]-4-yl]azo]-2,7-naphthalenedisulfonic acid trisodium salt-->N,N'-(3,3'-Dimethyl-4,4'-biphenyldiyl)bis(3-oxobutanamide)-->1,3,6-Naphthalenetrisulfonic acid, 8-hydroxy-7-[[4'-[(2-hydroxy-1-naphthalenyl)azo]-3,3'-dimethyl[1,1'-biphenyl]-4-yl]azo]-, trisodium salt-->BRILLIANT PURPURIN R-->trisodium 5-amino-3-[[4'-[(6-amino-1-hydroxy-3-sulphonato-2-naphthyl)azo]-3,3'-dimethyl[1,1'-biphenyl]-4-yl]azo]-4-hydroxynaphthalene-2,7-disulphonate-->Direct Black 24-->DIRECT ORANGE 6-->Evans Blue-->N,N'-(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(3-hydroxynaphthalene-2-carboxamide)-->Direct Black 154-->Direct Brown 222-->C.I. Direct Orange 31-->OXAMINE BLUE 4R-->Direct Brown 146-->DIRECT YELLOW 2 |
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