| Identification | Back Directory | [Name]
ethyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate | [CAS]
118988-04-8 | [Synonyms]
HO-PEG3-CH2COOEt
Hydroxy-PEG3-ethyl acetate
ethyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate | [Molecular Formula]
C10H20O6 | [MDL Number]
MFCD25956292 | [MOL File]
118988-04-8.mol | [Molecular Weight]
236.26 |
| Hazard Information | Back Directory | [Biological Activity]
Hydroxy-PEG3-ethyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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