| Identification | Back Directory | [Name]
1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE | [CAS]
112037-78-2 | [Synonyms]
-carboline
3-Methyl &alpha
Norharmane (9H-Pyrido[3,4-b]indole, ß
1,2,3,4-Tetrahydro-1-(trifluoromethyl)-ß
(S)-1-Trichloromethyl-1,2,3,4-Tetrahydro-&beta
rac 1-Trichloromethyl-1,2,3,4-Tetrahydro-&beta
1,2,3,4-Tetrahydro-1-(trifluoroMethyl)--carboline
1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE
1,2,3,4-TETRAHYDRO-1-(TRIFLUOROMETHYL)-BETA-CARBOLINE
1-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-beta-carboline
1-trifluoromethyl-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole
2,3,4,9-Tetrahydro-1-(trifluoromethyl)-1H-pyrido[3,4-b]indole
1-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-1-(trifluoromethyl)- | [Molecular Formula]
C12H11F3N2 | [MDL Number]
MFCD00052089 | [MOL File]
112037-78-2.mol | [Molecular Weight]
240.22 |
| Hazard Information | Back Directory | [Mechanism of action]
Although βCCE and other β-carbolines are not endogenous BZR
ligands (vide supra) and are not currently approved for clinical use, they are used to characterize different
GABAA/BZR subtypes (based on a and g subunit composition) and function (e.g., the partial agonist abecarnil)
toward the discovery of anxioselective drugs. In this regard, the β-carboline ring system is planar in comparison
to the boat conformation of the 1,4-benzodiazepines; thus, β-carbolines
have been useful to extend structure–activity relationship information for the agonist, antagonist, and inverse
agonist pharmacophores of the various GABAA/BZR subtypes. | [Clinical Use]
Several β-carbolines have approximately 10-fold higher affinity for the BZR when compared to diazepam. The ethyl
ester of β-carboline-3-carboxylic acid (βCCE), identified in human urine extracts as an artifact of the extraction
procedure, has very high affinity for the BZR. |
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