| Identification | Back Directory | [Name]
GLY-ARG-GLY-ASP-SER-PRO-LYS | [CAS]
111119-28-9 | [Synonyms]
GRGDSPK
EMD 56574
GLY-ARG-GLY-ASP-SER-PRO-LYS
H-GLY-ARG-GLY-ASP-SER-PRO-LYS-OH
GLY-ARG-GLY-ASP-SER-PRO-LYS ACETATE
GRGDSPK, FIBRONECTIN ATTACHMENT PEPTIDE
Gly-Arg-Gly-Asp-Ser-Pro-Lys >=97% (HPLC)
glycyl- arginyl-glycyl-aspartyl-seryl-prolyl-lysine
L-Lysine, glycyl-L-arginylglycyl-L-α-aspartyl-L-seryl-L-prolyl- | [Molecular Formula]
C28H49N11O11 | [MDL Number]
MFCD00076462 | [MOL File]
111119-28-9.mol | [Molecular Weight]
715.76 |
| Chemical Properties | Back Directory | [density ]
1.59±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
Solid | [pka]
3.60±0.21(Predicted) | [color ]
White to off-white | [biological source]
human |
| Hazard Information | Back Directory | [Uses]
Gly-Arg-Gly-Asp-Ser-Pro-Lys (RGD peptide) has been used-
- as a blocking peptide to inhibit integrin-fibronectin binding
- in adhesion assay performed on porcine trophectoderm to study the influence of TGFβ (transforming growth factor) on cell adhesion
- for incubation of MC3T3-E1 osteoblast cells to determine its effect on cell adhesion measured by AFM (atomic force microscopy)
- for the preparation of RGD.Flt23k.NR nanoparticles
- to determine the involvement of RGD-integrin bonding in cell adhesion process
| [General Description]
Gly-Arg-Gly-Asp-Ser-Pro-Lys is a RGD peptide. Naturally occurring RGD peptides, present in the ECM (extracellalar matrix) proteins, are involved in facilitating integrin-mediated cell adhesion to matrix proteins. RGD peptide is present as repeats in cell-adhesion protein, such as fibronectin and vitronectin. This tripeptide is recognized by cells by specific integrins (e.g. β1 , β3 , and β5 subunits), present on the cell surface and associated with the actin filament via the FA (focal adhesion)-complex. | [Biochem/physiol Actions]
Fibronectin analog that binds to integrins. |
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