| Identification | Back Directory | [Name]
HOLO-TRANSFERRIN | [CAS]
11096-37-0 | [Synonyms]
Optiferrin
SIDEROPHILIN
transferrins
APO-TRANSFERRIN
HUMAN TRASFERRIN
HOLO-TRANSFERRIN
Holotransferrins
HUMAN TRANSFERRIN
TRANSFERRIN (APO)
TRANSFERRIN (HOLO)
TRANSFERRIN, HUMAN
transferrin (serum)
APO-TRANSFERRIN RAT
APO-TRANSFERRIN DOG
APO-TRANSFERRIN SHEEP
Muscle trophic factor
apo-transferrin mouse
HUMAN SEROTRANSFERRIN
HUMAN APO-TRANSFERRIN
APO-TRANSFERRIN HUMAN
PARTIALLY IRON-LOADED
HUMAN HOLO-TRANSFERRIN
HOLO-TRANSFERRIN HUMAN
apo-transferrin bovine
APO-TRANSFERRIN,POWDER
Transferrin,Horse,~96%
Transferrin,Human,~94%
Transferrin, from Rat
TRANSFERRIN HUMAN (APO)
HOLO-TRANSFERRIN BOVINE
SIDEROPHILIN, IRON-POOR
TRANSFERRIN BOVINE (APO)
TRANSFERRIN, HOLO, HUMAN
TRANSFERRIN, APO-, HUMAN
TRANSFERRIN HUMAN (HOLO)
Bovine Transferrin - apo
TRANSFERRIN (HUMAN BLOOD)
TRANSFERRIN, HOLO, BOVINE
apo-transferrin guinea pig
apo-Transferrin from Human
apo-Transferrin from rat
holo-Transferrin from Human
SIDEROPHILIN, IRON-SATURATED
apo-Transferrin from sheep
apo-Transferrin from mouse
apo-Transferrin from rabbit
transferrin from bovine serum
TRANSFERRIN BOVINE (APO FORM)
SIDEROPHILIN, IRON-POOR HUMAN
TRANSFERRIN BOVINE (HOLO FORM)
TRANSFERRIN, HOLO, HUMAN PLASMA
TRANSFERRIN, APO-, HUMAN PLASMA
TRANSFERRIN, HOLO, BOVINE PLASMA
Transferrin, Apo-, Bovine Plasma
siderophilin,partially saturated
Human transferrin, Siderophilin
siderophilin, partially saturated
apo-Transferrin from guinea pig
APO-TRANSFERRIN RABBIT APPROX. 98%
APO-TRANSFERRIN (FROM HUMAN SERUM)
SIDEROPHILIN, IRON-SATURATED HUMAN
apo-Transferrin, Iron free, Powder
SIDEROPHILIN, PARTIALLY SATURATED HUMAN
apo-transferrin human cell culture*tested
Siderophilin, iron-saturated, Siderophilin
APO-TRANSFERRIN, BOVINE, CELL*CULTURE TE STED
Transferrin, Holo, Human Plasma, Low Endotoxin
APO-TRANSFERRIN HUMAN PARTIALLY*IRON-SAT URATED
transferrin bovine holo-form*iron-saturated cell
TRANSFERRIN, HUMAN, 98%, LOW ENDOTOXIN, PARTIALY SA
TRANSFERRIN (HOLO), FROM HUMAN PLASMA, PYROGEN-FREE
Transferrin Apo-, Human Plasma, Low Endotoxin Level
holo-Transferrin human,Siderophilin, iron-saturated
Transferrin human,Siderophilin, partially saturated
Transferrin, Apo-, Low Endotoxin Grade, Human Plasma
TRANSFERRIN BOVINE HOLO-FORM*IRON-SATURA TED CELL CU
APO-TRANSFERRIN HUMAN GAMMA-IRRADIATED*C ELL CULTURE
Transferrin, Apo-, Tissue Culture Grade, Human Plasma
apo-Transferrin human,Human transferrin, Siderophilin
Transferrin, Holo, TC Grade, Pyrogen-Free, Human Plasma
Transferrin, Apo-, TC Grade, Pyrogen-Free, Human Plasma
APO-TRANSFERRIN, HUMAN, APPROX 97% ENDOT OXIN TESTED, CELL CULTURE TESTED
HOLO-TRANSFERRIN,HUMAN, APPROX. 97% ENDO TOXIN TESTED, CELL CULTURE TESTED | [EINECS(EC#)]
234-318-8 | [Molecular Formula]
n.a. | [MDL Number]
MFCD00131337 | [MOL File]
11096-37-0.mol | [Molecular Weight]
362.384 |
| Questions and Answers (Q&A) | Back Directory | [Description]
Holo-transferrin is the transferrin of the holo iron. It is a kind of iron-binding blood plasmaglycoproteins that is capable of regulating the level of free iron (Fe) in biological fluids. It is responsible for iron transportation in vertebrate serum and donating irons to cells through interaction with the CD71 membrane receptor. Transferrin is crucial for proliferating cells as a growth factor to initiate and maintain the DNA synthesis. It can also act as a cytokine. It is mainly synthesized in liver inside the human body. It is responsible to deliver iron from duodenum and white blood cells macrophages to all the other tissues, and is a key protein to maintain in vivo iron homeostasis. Increased plasma transferrin level is related to diseases such as iron deficiency anemia while decrease plasma transferrin is related to iron overload diseases and protein malnutrition.
| [References]
https://en.wikipedia.org/wiki/Transferrin
http://www.prospecbio.com/Holo_Transferrin_Human_11_121/
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| Hazard Information | Back Directory | [Uses]
Transferrin (Holo) is the primary iron binding and cell delivery molecule present in serum. Serum-free cell culture systems require a delivery format for iron. It is the preferential delivery form of iron because cells process transferrin bound iron in a physiologically appropriate way through transferrin receptors on the cell surface. It can be used with a wide range of cells types. It is loaded with iron prior to use and can be added directly to iron poor or iron-free cell culture media. It has been used for study in treatment of breast cancer cells with holo-transferrin in combination with dihydroartemisinin results in increased tumor cell death due to elevated levels of intracellular ferrous iron. | [Definition]
ChEBI: Protirelin is a tripeptide composed of L-pyroglutamyl, L-histidyl and L-prolinamide residues joined in sequence. It has a role as a human metabolite. It is a peptide hormone and a tripeptide. | [General Description]
Transferrin is an 80 kDa serum glycoprotein, which has an half-life of 8 to 10 days. The gene is located on human chromosome 3q22.1. Transferrin is expressed in hepatocytes. | [Pharmaceutical Applications]
Transferrins are a group of proteins that are abundant in blood and their primary role is to transport Fe3+,
as free Fe3+ would be toxic to most organisms. Transferrin consists of a single polypeptide chain independently
binding a maximum of two Fe3+ ions. Fe3+ is bound in a hexa-coordinated high-spin complex
within the protein. The metal is coordinated by the N atom from the imidazole residue, two deprotonated
phenol groups, a carboxylate and a carbonato ligand. | [Biochem/physiol Actions]
Studies have shown that co-treatment of breast cancer cells with holo-transferrin, which increases iron levels within cells and derivatives of artemisinin results in increased cell death. | [Purification Methods]
This transferrin is purified by affinity chromatography on phenyl-boronate agarose followed by DEAE-Sephacel chromatography. The product is free from haemopexin. [Cook et al. Anal Biochem 149 349 1985, Aisen & Listowsky Ann Rev Biochem 49 357 1980.] |
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