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ChemicalBook--->CAS DataBase List--->110429-45-3

110429-45-3

        110429-45-3 Structure

        110429-45-3 Structure
        IdentificationBack Directory
        [Name]

        Triethylene Glycol 2-Bromoethyl Methyl Ether
        [CAS]

        110429-45-3
        [Synonyms]

        mPEG4-Br
        m-PEG4-bromo
        m-PEG4-bromide
        Br-(CH2CH2O)4-Me
        Bromo-PEG4-methoxy
        Methyl-PEG4-bromide
        1-Bromo-3,6,9,12-tetraoxatridecane
        13-Bromo-2,5,8,11-tetraoxatridecane
        2,5,8,11-Tetraoxatridecane, 13-bromo-
        Triethylene Glycol 2-Bromoethyl Methyl Ether
        2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethyl Bromide
        2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethyl Bromide 1-Bromo-3,6,9,12-tetraoxatridecane
        [Molecular Formula]

        C9H19BrO4
        [MDL Number]

        MFCD12545963
        [MOL File]

        110429-45-3.mol
        [Molecular Weight]

        271.149
        Chemical PropertiesBack Directory
        [Boiling point ]

        296.3±25.0 °C(Predicted)
        [density ]

        1.256±0.06 g/cm3(Predicted)
        [refractive index ]

        1.4620 to 1.4660
        [storage temp. ]

        2-8°C
        [form ]

        clear liquid
        [color ]

        White to Yellow to Green
        [CAS DataBase Reference]

        110429-45-3
        Safety DataBack Directory
        [HS Code ]

        2909.19.6000
        Hazard InformationBack Directory
        [Description]

        m-PEG4-bromide is a PEG linker containing a bromide group. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
        [Biological Activity]

        Triethylene Glycol 2-Bromoethyl Methyl Ether is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs) of trastuzumab (HY-P9907). It was placed distal to the monomethyl auristatin E (MMAE) payload to generate ADCs with altered hydrophilicity, antigen binding and in vitro potency. Tetraethylene glycol monotosylate can also be used as a linker of PROTAC, which can be used for the synthesis of PROTAC.
        [in vitro]

        ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

        [target]

        Cleavable

        PEGs

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