| Identification | Back Directory | [Name]
ACT-132577 | [CAS]
1103522-45-7 | [Synonyms]
ACT-132577
Aprocitentan
Despropyl Macitentan
Macitentan ACT-132577
Macitentan Impurity 07
N-Despropyl Macitentan
Macitentan ACT-132577-D4
Macitentan N-Despropyl Impurity
APROCITENTAN; ACT-132577; ACT 132577; ACT132577; DESPROPYL MACITENTAN
N-[5-(4-bromophenyl)-6-[2-(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl
5-(4-BROMOPHENYL)-4-[2-(5-BROMOPYRIMIDIN-2-YL)OXYETHOXY]-6-(SULFAMOYLAMINO)PYRIMIDINE
N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]sulfamide
5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(sulfamoyl)pyrimidin-4-amine
Sulfamide, N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]- | [Molecular Formula]
C16H14Br2N6O4S | [MDL Number]
MFCD28155267 | [MOL File]
1103522-45-7.mol | [Molecular Weight]
546.19 |
| Chemical Properties | Back Directory | [Melting point ]
139-141°C | [Boiling point ]
705.0±70.0 °C(Predicted) | [density ]
1.841±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly, Heated), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
13.56±0.60(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
N-Despropyl-macitentan, is an active metabolite which is part of a family of endothelin receptor antagonist that allows for treatment of pulmonary arterial hypertension (PAH) | [Definition]
ChEBI: ACT-132577 is a member of the class of sulfamides in which one of the amino groups of sulfonamide is substituted by a 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl group. An active metabolite of macitentan (obtained by oxidative depropylation), an orphan drug used for the treatment of pulmonary arterial hypertension. It has a role as an antihypertensive agent, an endothelin receptor antagonist, a drug metabolite and a xenobiotic metabolite. It is an aromatic ether, an organobromine compound, a member of pyrimidines and a member of sulfamides. It is functionally related to an ethylene glycol. | [storage]
Store at -20°C |
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