| Identification | Back Directory | [Name]
ALPHA-BUNGAROTOXIN | [CAS]
11032-79-4 | [Synonyms]
α-BuTX
ALPHA-BGT
ALPHA-BUTX
α-Bungotoxin
α-Bungarotoxin
A-BUNGAROTOXIN
ALPHA-BUNGAROTOXIN
TIANFU-CHEM - ALPHA-BUNGAROTOXIN
M.W. 7984.14 C338H529N97O105S11
BUNGARUS MULTICINCTUS TOXIN, ALPHA
A-BUNGAROTOXIN FROM THE VENOM OF THE
ALPHA-BUNGAROTOXIN, BUNGARUS MULTICINCTUS
α-Bungarotoxin, Bungarus multicinctus - CAS 11032-79-4 - Calbiochem
H-ILE-VAL-CYS-HIS-THR-THR-ALA-THR-SER-PRO-ILE-SER-ALA-VAL-THR-CYS-PRO-PRO-GLY-GLU-ASN-LEU-CYS-TYR-ARG-LYS-MET-TRP-CYS-ASP-ALA-PHE-CYS-SER-SER-ARG-GLY-LYS-VAL-VAL-GLU-LEU-GLY-CYS-ALA-ALA-THR-CYS-PRO-SER-LYS-LYS-PRO-TYR-GLU-GLU-VAL-THR-CYS-CYS-SER-THR-ASP-LYS-CYS-ASN-PRO-HIS-PRO-LYS-GLN-ARG-PRO-GLY-OH | [EINECS(EC#)]
234-266-6 | [Molecular Formula]
C338H529N97O105S11 | [MDL Number]
MFCD01779815 | [MOL File]
11032-79-4.mol | [Molecular Weight]
895.082 |
| Chemical Properties | Back Directory | [Definition]
A protein that binds specifically to acetylcholine
receptors.
| [Appearance]
Single polypeptide weight; molecular
weight of 8000.
| [storage temp. ]
−20°C
| [solubility ]
Soluble in sterile water | [form ]
solid
| [color ]
white
| [Water Solubility ]
Soluble in water | [CAS DataBase Reference]
11032-79-4 |
| Hazard Information | Back Directory | [Chemical Properties]
Single polypeptide weight; molecular
weight of 8000.
| [Hazard]
Nuerotoxic. | [General Description]
Blocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor (Kd = 1 pM to 1 nM) but does not depress acetylcholine release from motor nerve endings. Blocks nicotine-induced increase of intracellular Ca2+ in PC12 cells (IC50 = 310 nM), and prevents opening of nicotinic receptor-associated ion channels. Reconstitution experiments in Xenopus oocytes have shown the effects of α-bungarotoxin on neuronal nAChR to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 >3 μM). | [Biochem/physiol Actions]
Product does not compete with ATP. | [storage]
-20°C (desiccate) |
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