| Identification | Back Directory | [Name]
ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN | [CAS]
11002-13-4 | [Synonyms]
DRVYIHPFHLVIHN
ANGIOTENSINOGEN
RENIN SUBSTRATE
hypertensinogen
ANGIOTENSINOGEN 1-14
RENIN SUBSTRATE, HUMAN
PREANGIOTENSINOGEN 1-14
HUMAN PREANGIOTENSINOGEN 1-14
ANGIOTENSINOGEN FRAGMENT 1-14
ANGIOTENSINOGEN (1-14) (HUMAN)
RENIN SUBSTRATE TETRADECAPEPTIDE
PREANGIOTENSINOGEN (1-14) (HUMAN)
angiotensinogen from human plasma
Hypertensinogen, Renin substrate
RENIN SUBSTRATE TETRADECAPEPTIDE HUMAN
TETRADECAPEPTIDE RENIN SUBSTRATE (HUMAN)
ANGIOTENSINOGEN FROM HUMAN PLASMALYOPHIL IZED
ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN
ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN-OH
H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN-OH | [Molecular Formula]
C83H122N24O19 | [MDL Number]
MFCD00133096 | [MOL File]
11002-13-4.mol | [Molecular Weight]
1760.01 |
| Hazard Information | Back Directory | [Uses]
Angiotensinogen has been used for the detection and analysis of the complexes formed between angiotensinogen and proform of eosinophil major basic protein (ProMBP) in both serum and amniotic fluid during pregnancy through ELISA. | [Biological Functions]
Human plasma contains a glycoprotein called angiotensinogen,
which serves as the only known substrate
for renin. Angiotensinogen must undergo proteolysis
before active portions of the protein are sufficiently unmasked
to exert biological effects. Angiotensinogen is
synthesized in many organs, including the liver, brain,
kidney, and fat. Its gene transcription and plasma concentrations
increase following treatment with adrenocorticotropic
hormone (ACTH), glucocorticoids, thyroid
hormone, and estrogens, as well as during
pregnancy and inflammation and after nephrectomy.
Angiotensinogen also has been found in large quantities
in cerebrospinal and amniotic fluid. Mutations in
the angiotensinogen gene have been reported to be
linked to human hypertension. | [Biological Activity]
Angiotensinogen acts as a precursor molecule in the renin-angiotensin-aldosterone system (RAAS) pathway. It is a part of the renin-angiotensin system th at regulates blood pressure and fluid balance. Moreoveroveractivation of the RAAS system has been associated with the development of several types of cancercardiovascular and renal diseases. Furthermorein certain cancers angiotensin II has been shown to promote cancer metastasis. |
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SIGMA-RBI
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800 736 3690 (Orders) |
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www.sigma-aldrich.com |
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