| Identification | Back Directory | [Name]
FIN56 | [CAS]
1083162-61-1 | [Synonyms]
FIN56
FIN-56;FIN 56
FIN56 >=98% (HPLC)
FIN56;FIN-56 ;FIN 56
N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide
9H-Fluorene-2,7-disulfonamide, N2,N7-dicyclohexyl-9-(hydroxyimino)-
FIN56 N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide
inhibit,GPX4,FIN56,Ferroptosis,degradation,FIN 56,Inhibitor,squalene,synthase,FIN-56 | [Molecular Formula]
C25H31N3O5S2 | [MDL Number]
MFCD30480929 | [MOL File]
1083162-61-1.mol | [Molecular Weight]
517.66 |
| Chemical Properties | Back Directory | [Boiling point ]
759.1±70.0 °C(Predicted) | [density ]
1.50±0.1 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
Soluble in DMSO (>25 mg/ml) | [form ]
powder | [pka]
10.10±0.20(Predicted) | [color ]
white to beige | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| Hazard Information | Back Directory | [Description]
FIN56 (1083162-61-1) is a novel inducer of ferroptosis acting via degradation of GPX4 and activation of squalene synthase (leading to CoQ10 depletion, a compound which inhibits ferroptosis via an unknown mechanism).1? FIN56 inhibited glioblastoma growth in vitro and in vivo via induction of ferroptosis as well as lysosomal membrane permeabilization.2 | [Definition]
ChEBI: FIN56 is a fluorene that is N-9H-fluoren-9-ylidenehydroxylamine substituted by N-cyclohexylsulfonyl groups at positions 2 and 7. It induces ferroptosis via degradation of GPX4 and also binds and activates squalene synthase. It has a role as a ferroptosis inducer and an EC 1.11.1.9 (glutathione peroxidase) inhibitor. It is a member of fluorenes, a ketoxime and a sulfonamide. It is functionally related to a 9-hydroxyiminofluorene-2,7-disulfonamide. | [Biochem/physiol Actions]
Ferroptosis inducer 56 (FIN56) is a member of the class 3 ferroptosis inducers. | [storage]
Store at +4°C | [References]
Shimada et al. (2016), Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis; Chem. Biol. 12 497
Zhang et al. (2021), FIN56, a novel ferroptosis inducer, triggers lysosomal membrane permeabilization in a TFEB-dependent manner in glioblastoma; Cancer 12 6610 |
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