| Identification | Back Directory | [Name]
Benzonitrile, 4-(2-hydroxycyclohexyl)-2-(trifluoromethyl)- | [CAS]
1076225-26-7 | [Synonyms]
(rac)-PF-998425
Benzonitrile, 4-(2-hydroxycyclohexyl)-2-(trifluoromethyl)- | [Molecular Formula]
C14H14F3NO | [MOL File]
1076225-26-7.mol | [Molecular Weight]
269.26 |
| Chemical Properties | Back Directory | [Boiling point ]
365.2±42.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (371.39 mM; Need ultrasonic) | [form ]
Solid | [pka]
14.84±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
(rac)-PF-998425 is a potent, selective, nonsteroidal androgen receptor (AR) antagonist. (rac)-PF-998425 has IC50 values of 26 and 90 nM in the AR binding and cellular assays, respectively. (rac)-PF-998425 has the potential for the research of the androgenetic alopecia[1]. | [References]
[1]. Li JJ, et al. Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. J Med Chem. 2008;51(21):7010-7014. |
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