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ChemicalBook--->CAS DataBase List--->106021-96-9

106021-96-9

106021-96-9 Structure

106021-96-9 Structure
IdentificationBack Directory
[Name]

VAL-GLN-GLY-GLU-GLU-SER-ASN-ASP-LYS
[CAS]

106021-96-9
[Synonyms]

Sclavo peptide
IL-1B (163-171) (HUMAN)
interleukin-1beta(163-171
IL-1BETA (163-171) (HUMAN)
INTERLEUKIN-1B (163-171) (HUMAN)
Interleukin-1β (163-171) (human)
β-Interleukin I (163-171), human
b-Interleukin I (163-171), human
β-Interleukin I (163-171), human
BETA-INTERLEUKIN I (163-171), HUMAN
VAL-GLN-GLY-GLU-GLU-SER-ASN-ASP-LYS
INTERLEUKIN-1BETA (163-171) (HUMAN)
interleukin-1B fragment 163-171 human
interleukin-1β fragment 163-171 human
Interleukin-1β Fragment 163-171 human
H-VAL-GLN-GLY-GLU-GLU-SER-ASN-ASP-LYS-OH
INTERLEUKIN-1BETA FRAGMENT 163-171 HUMAN
IL-1β (163-171) (human)|β-Interleukin I (163-171),human
IL-1β (163-171) (human)|β-Interleukin I (163-171),human
L-Lysine, L-valyl-L-glutaminylglycyl-L-α-glutamyl-L-α-glutamyl-L-seryl-L-asparaginyl-L-α-aspartyl-
[Molecular Formula]

C39H64N12O19
[MDL Number]

MFCD00076554
[MOL File]

106021-96-9.mol
[Molecular Weight]

1004.99
Chemical PropertiesBack Directory
[Boiling point ]

1682.6±65.0 °C(Predicted)
[density ]

1.419±0.06 g/cm3(Predicted)
[storage temp. ]

−20°C
[solubility ]

insoluble in EtOH; ≥100.4 mg/mL in DMSO; ≥24.75 mg/mL in H2O
[form ]

solid
[pka]

3.14±0.10(Predicted)
Safety DataBack Directory
[WGK Germany ]

3
Spectrum DetailBack Directory
[Spectrum Detail]

VAL-GLN-GLY-GLU-GLU-SER-ASN-ASP-LYS(106021-96-9)MS
Hazard InformationBack Directory
[Biological Activity]

β-interleukin i (163-171), human(c39h64n12o19), a peptide with the sequence val-gln-gly-glu-glu-ser-asn-asp-lys, mw= 1005. interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes). interleukin 1 alpha and interleukin 1 beta (il-1 alpha and il-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis.interleukin-1 beta (il-1β) also known as catabolin, is a cytokine protein that in humans is encoded by the il1b gene. il-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). cytosolic thiol protease cleaves the product to form mature il-1β. il-1β is a member of the interleukin 1 cytokine family. this cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.figure1 formula of b-interleukin i (163-171), humanfigure2 structure of b-interleukin i
[Biochem/physiol Actions]

IL1B (interleukin 1 β) is an immune-activating cytokine. In presence of infection or cell stress, it gets converted into active mature form.
[storage]

Store at -20°C
[References]

1. Contassot E, Beer HD, French LE (2012). "Interleukin-1, inflammasomes, autoinflammation and the skin". Swiss Med Wkly 142: w135902. Matzinger P (2012). "The evolution of the danget theory. Interview by Lauren Constable, Commissioning Editor". Expert Rev Clin Immunol 8 (4): 311-7.3. Sahoo M, Ceballos-Olvera I, del Barrio L, Re F (2011). "Role of the inflammasome, IL-1β, and IL-18 inbacterial infections". ScientificWorldJournal 11: 2037-50.
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