| Hazard Information | Back Directory | [Description]
L-threo Lysosphingomyelin is an endogenous bioactive sphingolipid and isomer of lysosphingomyelin .1 It is an agonist of sphingosine-1-phosphate (S1P) receptors 1-3 (EC50s = 19.3, 313.3, and 131.8 nM for human S1P1-3, respectively). As this product is derived from a natural source, there may be variations in the sphingoid backbone. | [References]
1. Im, D.-S., Clemens, J., Macdonald, T.L., et al. Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): Structure-activity relationship of sphingosine1-phosphate receptors Biochemistry 40(46),14053-14060(2001). |
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