| Identification | Back Directory | [Name]
1H-Indole-3-acetamide, 4-[1-methyl-2-oxo-2-[(phenylsulfonyl)amino]ethoxy]-2-(2-methylpropyl)-α-oxo-1-(phenylmethyl)- | [CAS]
1048660-43-0 | [Synonyms]
ROC-0929
1H-Indole-3-acetamide, 4-[1-methyl-2-oxo-2-[(phenylsulfonyl)amino]ethoxy]-2-(2-methylpropyl)-α-oxo-1-(phenylmethyl)- | [Molecular Formula]
C30H31N3O6S | [MOL File]
1048660-43-0.mol | [Molecular Weight]
561.65 |
| Hazard Information | Back Directory | [Biological Activity]
ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A2 (sPLA2s) with an IC50 of 80 nM, specially targeting hGX. ROC-0929 inhibits the phosphorylation of ERK1/2 and p-38. Secreted phospholipases A2 (sPLA2s) are a family of disulfide-rich, Ca2+-dependent enzymes that hydrolyze the sn-2 position of glycero-phospholipids to release a fatty acid and a lysophospholipid. ROC-0929 has the potential for researching inflammation related diseases[1]. | [storage]
Store at -20°C | [References]
[1]. Oslund RC, et al. Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2. J Med Chem. 2008;51(15):4708-4714.
[2]. Hallstrand TS, et al. Endogenous secreted phospholipase A2 group X regulates cysteinyl leukotrienes synthesis by human eosinophils. J Allergy Clin Immunol. 2016;137(1):268-277.e8. |
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