| Identification | Back Directory | [Name]
1H-Indole-5-carboxamide, 1-[1-[2-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-2-oxoethyl]-4-piperidinyl]-2,3-dihydro-N-methyl-2-oxo- | [CAS]
1037837-27-6 | [Synonyms]
1H-Indole-5-carboxamide, 1-[1-[2-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-2-oxoethyl]-4-piperidinyl]-2,3-dihydro-N-methyl-2-oxo- | [Molecular Formula]
C24H32N4O3 | [MOL File]
1037837-27-6.mol | [Molecular Weight]
424.54 |
| Hazard Information | Back Directory | [Description]
ARN 14494 is a potent serine palmitoyltransferase inhibitor (SPT; IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes. |
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