| Identification | Back Directory | [Name]
9-ING-41 | [CAS]
1034895-42-5 | [Synonyms]
9-ING-41
9-ING-41 USP/EP/BP
3-(5-Fluoro-3-benzofuranyl)-4-(5-methyl-5H-1,3-dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione | [Molecular Formula]
C22H13FN2O5 | [MDL Number]
MFCD16495778 | [MOL File]
1034895-42-5.mol | [Molecular Weight]
404.35 |
| Questions And Answer | Back Directory | [Use]
9-ING-41 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with antitumor activity. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β. | [In vivo]
9-ING-41 has single-agent antitumor activity in a mouse model of MCL. Mouse xenograft studies shows that the combination of clinically relevant doses of CPT-11 and 9-ING-41 lead to greater antitumor effect than is observed with either agent alone.
| [In vitro]
9-ING-41, a clinically relevant small molecule GSK-3β inhibitor with broad spectrum pre-clinical antitumor activity, suppresses the growth of neuroblastoma cells.9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β. |
| Chemical Properties | Back Directory | [Boiling point ]
649.5±55.0 °C(Predicted) | [density ]
1.63±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 2 mg/ml; DMSO: 1 mg/ml; Ethanol: insol; PBS (pH 7.2): insol | [form ]
A solid | [pka]
7.23±0.60(Predicted) | [color ]
Pink to red |
| Hazard Information | Back Directory | [Uses]
3-(5-Fluoro-3-benzofuranyl)-4-(5-methyl-5H-1,3-dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione induces apoptosis in human ovarian cells and also inhibits tumor growth in xenografted rat. |
|
| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
http://www.is0513.com/ShowSupplierProductsList927327/0.htm |
|