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ChemicalBook--->CAS DataBase List--->103429-31-8

103429-31-8

103429-31-8 Structure

103429-31-8 Structure
IdentificationBack Directory
[Name]

CTOP
[CAS]

103429-31-8
[Synonyms]

NTB
CTOP
NALTRIBEN
threoninamide
CYS2,TYR3,ORN5,PEN7-AMIDE
M.W. 1062.26 C50H67N11O11S2
(Tyr3,Orn5,Pen7)-Octreotate amide
Cys2, Tyr3, Orn5, Pen7 amide - CTOP
DPHE-CYS-TYR-DTRP-ORN-THR-PEN-THR-OL
D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2
CTOP, (Tyr3,Orn5,Pen7)-Octreotate aMide
D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR AMIDE
H-D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2
FCYW(ORN)T(PEN)T-NH2 (DISULFIDE BRIDGE: 2-7)
[Cys2, Tyr3, Orn5, Pen7-amide]-Somatostatin 14 (7-14)
[CYS2, TYR3, ORN5, PEN7]-SOMATOSTATIN 14 (7-14), AMIDE
D-Phe-L-Cys(1)-L-Tyr-D-Trp-L-Orn-L-Thr-L-Pen(1)-L-Thr-NH2
H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (Disulfide bond)
H-D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2 (DISULFIDE BRIDGE: 2-7)
D-Phe-L-Cys(1)-L-Tyr-D-Trp-L-Orn-L-Thr-3-Mercapto(1)-L-Val-L-Thr-NH2
phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)
H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2, (Disulfide bond between Cys2 and Pen7)
phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide
L-Threoninamide, D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-ornithyl-L-threonyl-3-mercapto-L-valyl-, cyclic (2→7)-disulfide
[Molecular Formula]

C50H67N11O11S2
[MDL Number]

MFCD00076708
[MOL File]

103429-31-8.mol
[Molecular Weight]

1062.26
Chemical PropertiesBack Directory
[Boiling point ]

1491.2±65.0 °C(Predicted)
[density ]

1.42±0.1 g/cm3(Predicted)
[RTECS ]

XO8578200
[storage temp. ]

-20°C
[form ]

Powder
[pka]

9.90±0.15(Predicted)
[Water Solubility ]

Soluble to 1 mg/ml in water
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

CTOP has been used:
  • to study the anxiogenic effects induced by CTOP in mice and rat.
  • to study the effect of μ-opioid antagonist, CTOP on the bovine milk-derived LF (BLF)-induced analgesia.
  • to determine whether μ-opioid receptors act cooperatively with 5-hydroxytryptamine (5-HT1A) receptors to regulate the behaviors generated in the elevated T-maze (ETM).
[Uses]

CTOP is a μ-opioid receptor antagonist which has been shown to regulate behaviour and expression in rats. An endogenous opioid peptide which may also be used in the treatment of pain through improved morphine tolerance via blocking of mTOR.
[General Description]

D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) is a selective cyclic μ-opioid receptor antagonist.
[Biochem/physiol Actions]

Selective ligand for μ-opioid receptors.
[storage]

Store at -20°C
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