| Identification | Back Directory | [Name]
PF-04457845 | [CAS]
1020315-31-4 | [Synonyms]
CS-1549
PF-04457845
PF-04457845;PF04457845
PF-04457845 >=98% (HPLC)
N-Pyridazin-3-yl-4-(3-{[5-(trifluoroMethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxaMide
N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide
N-pyridazin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]piperidine-1-carboxamide
1-Piperidinecarboxamide, n-3-pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2- pyridinyl]oxy]phenyl]methylene]- | [Molecular Formula]
C23H20F3N5O2 | [MDL Number]
MFCD18782721 | [MOL File]
1020315-31-4.mol | [Molecular Weight]
455.43 |
| Chemical Properties | Back Directory | [Boiling point ]
687.0±55.0 °C(Predicted) | [density ]
1.389±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml | [form ]
powder | [pka]
12.72±0.20(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Biochem/physiol Actions]
PF-04457845 is a potent, orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. PF-04457845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It was shown to be both potent and selective against other serine hydrolases. It has an IC50 value of 7.2 nM for human FAAH. The endocannabinoid system is a target for therapeutic pain relief. In a rat model of inflammatory pain, PF-04457845 produced significant reduction of inflammatory pain with efficacy comparable to that of naproxen at 10 mg/kg. | [storage]
Store at +4°C |
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