| Identification | Back Directory | [Name]
MICROCYSTIN YR | [CAS]
101064-48-6 | [Synonyms]
MICROCYSTIN YR
Cyanoginosin yr
Cyanoginosin-yr
Microcystin YR (9CI)
MICROCYSTIN-YR SOLUTION
Cyanoginosin la, 3-tyrosyl-5-arginine-
Cyanoginosin la, 3-L-tyrosyl-5-L-arginine
Cyanoginosin la, 3-L-tyrosine-5-L-arginine
microcystin yr from microcystis aeruginosa
Cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-tyrosyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl] | [EINECS(EC#)]
621-458-3 | [Molecular Formula]
C52H72N10O13 | [MDL Number]
MFCD00236437 | [MOL File]
101064-48-6.mol | [Molecular Weight]
1045.19 |
| Hazard Information | Back Directory | [Uses]
Analog of microcystin-LR with Tyr substituted in place of Leu. As for all microcystins the conjugated double bonds in the ADDA moiety cause a characteristic absorption maximum at 238nm. The Tyr residue in position 2 of microcystin-YR confers an absorption maximum at 232nm. Potent inhibitor of eukaryotic protein phosphatases 1 and 2A. Useful as a reference compound in environmental analysis. The hydroxyl group of the Tyr residue may prove useful for linking microcystin-YR via conjugation to other chemicals. Inhibits the synthesis of proteases such as cathepsin D and L, and arginine aminopeptidase. | [General Description]
Microcystin is a potent cyanotoxin produced by the bloom of Microcystis aeruginosa. It is harmful to aquatic animals. It is a heptapeptide and exists as multiple variant forms. pCO2 and nitrogen levels modulate the toxic variants levels. It elicits damage to the liver and other organs. | [Biochem/physiol Actions]
Microcystin YR inhibits protein phosphatase type 2A and protein phosphatase type 1. Toxicity to undifferentiated cells was seen by inhibition of neutral red uptake, >80% at 100 μM, after 48 h. |
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