| Identification | Back Directory | [Name]
11-DEOXY-11-METHYLENE PROSTAGLANDIN D2 | [CAS]
100648-29-1 | [Synonyms]
ROZAFJXVUNORLT-SFIVEXQWSA-N
11-DEOXY-11-METHYLENE PROSTAGLANDIN D2
11-deoxy-11-methylene Prostaglandin D2
9ALPHA,15S-DIHYDROXY-11-METHYLENE-PROSTA-5Z,13E-DIEN-1-OIC ACID
Prosta-5,13-dien-1-oic acid, 9,15-dihydroxy-11-methylene-, (5Z,9α,13E,15S)- | [Molecular Formula]
C21H34O4 | [MDL Number]
MFCD03411989 | [MOL File]
100648-29-1.mol | [Molecular Weight]
350.49 |
| Hazard Information | Back Directory | [Uses]
Prostaglandin D2 (PGD2; ) is one of the five primary enzymatic prostaglandins derived directly from PGH2 . PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, leukocyte-type PGD synthase. 11-deoxy-11-methylene PGD2 is a novel, chemically stable, isosteric analog of PGD2 wherein the 11-keto group is replaced by an exocyclic methylene. In the PGE series, the analogous modification leads to a stable, somewhat less potent agonist which embodies the same uterine stimulant and cervical ripening activities as the parent prostaglandin. However, 11-deoxy-11-methylene PGD2 has been reported by one group to be essentially without agonist activity on human platelets, a DP1 receptor assay.
| [Definition]
ChEBI:11-deoxy-11-methylene-PGD2 is a prostanoid. |
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